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It is applied daily to rash prone areas.
If he got real irritated I would use a bit more Desitin. Hospice provided 2 ointments one a regular barrier cream that contained Zinc the other a more medicated one that contained Calamine lotion. These are the 2 that I mixed and used daily if he had no redness.
Both of these are pretty thick and it is best not to rub them on but apply some to your gloved hands and "pat" it on. This applies an thin even coating. Trying to remove or wipe off excess cream or ointment can be just as irritating to the skin.
This sounds sort of "out there" but if FIL is in bed often if you can open the tab brief (I did like the term "diaper" for adult incontinence products) and allow the skin to be exposed to the air. You can put a brief under him and one over but don't fasten the tabs. Sometimes exposure to the air allows the are to dry better and bacteria love a warm moist area this eliminates both.
If it does not clear or becomes worse I would have it checked it is possible that a medicated product might be necessary. If he is on Hospice or has a visiting nurse have them check it.
If he is not drinking enough fluids that can also concentrate the urine and make it harsher to the skin so increase fluids. Yes you will probably have to change him more often until his body gets used to the increase. but better more changes than broken down skin or UTI's