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People who use supplemental oxygen to breath can be at risk for nosebleeds because the nasal prongs can cause trauma to, or irritate, the inside of their noses. In this situation, two recommendations are to humidify the oxygen or switch to an oxygen mask instead of the nasal prongs. Nasal saline sprays also can help.

Mayo Clinic advice see link below


https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/nosebleeds-minor-to-serious#:~:text=People%20who%20use%20supplemental%20oxygen,instead%20of%20the%20nasal%20prongs.
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How much flow and is there a humidifier included?
A constant or frequent nosebleed may need treatment by an ENT physician.
If the flow rate is high like greater than 5 liters he might need a heated humidifier. That may be a battle with the insurer. Sometimes the ordering physician of the oxygen can try to get additional equipment by communicating with the insurer as a medically needed device. Start by contacting the doctors office to update his appointment.
He might also tolerate switching to an oxygen mask every few hours. Just watch skin condition at the bridge of the nose.
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MUST use distilled water
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