Is there anything besides or in addition to Sinemet, Seroquel and Trazodone for my mom in the last stage of Parkinson’s with Lewy Body Dementia?

One of the best options you have is HOSPICE.
If mom is in last stages Hospice can help you navigate End Of Life. They can try as best they can to make sure that she is comfortable and pain free.
You will have the supplies you need and the support of a great team of dedicated people.
If you are asking if there are any drugs or methods that will extend her life I am sure her doctors have done what they can and medication can only do so much.
Let Hospice help her and you now.

First off, what does her Dr say? What are these drugs being used for? Pain? Tremors & Movement Issues? Psych issues? Anxiety? Inability to sleep? Behavior? The answer to your question would lie in what exactly is you're looking for the drugs to do. What about stopping all those meds and letting her brain work? Just a thought. My mom declined drastically with drugs and flourished/improved when all mind-altering drugs were stopped and she was able to think as straight as her dementia would allow. She was so happy about! The fog from the drugs was much worse for her than the fog from what in her case was mild dementia exacerbated by hospital/surgical delirium. I'm no expert on Parkinson's of Lewy Body Dementia though. Just sharing my thoughts and my mom's experience. Wishing you the best. I know it's so difficult to see our parent's suffer/decline.

I can only offer my experience. My mom is on the end of the spectrum with all Lewy body dementia and no Parkinson's symptoms, so she is not a candidate for the new, incredibly expensive ($1400 a month) drug Nuplazid (pimavanserin) according to her insurance. Remeron (mirtazapine) is supposedly helpful for the hallucinations also, but she hasn't tried that recently. For her, Seroquel has been very effective at controlling the hallucinations and delusions and stabilizing her mood, at least when she doesn't have a urinary tract infection. It's always worth checking for a urinary tract infection. Each time my mom has gone uncontrollably, violently combative with raging hallucinations and delusions (police came twice), on hospitalization she was treated for urinary tract infection and once again became a sweet little old lady. She is now on a daily antibiotic for prevention of urinary tract infection. We do have Depakote (divalproex) and Ativan (lorazepam) for use in emergency (they did help), but there's been no need to use them since starting the preventive antibiotic.

Kdeep working with the doctors

Those were pretty much the meds my dad had at the end of Parkinson's. For the last 2.5 months he was mostly in-patient hospice. Good luck with this and do not hesitate to ask for help. It will bring you such peace.

I suggest checking out the Lewy Body resource center


https://lewybodyresourcecenter.org/what-is-lbd/treatment-important-information/medications/

You should ask a neurologist or GP to make sure there is something else going on.
My husband with Parkinson’s was in advanced stage now he is not, he got better with change of meds.
Parkinson is unpredictable, but nobody dies from it. So not sure how they determine that?

My dad has PD with Parkinson's Dementia. He is on Sinement of course, and has taken Trazadone in the past for sleep. Seroquel can affect people differently - for some it helps with the delusions/hallucinations, for others it makes them worse. My uncle had a terrible experience with Seroquel, almost killed him, it made him much worse, he had dementia. My father is 90 and recently had to be placed in a NH due to end-stage Parkinson's, CHF, incontincence, T2 diabetes, and a very bad fall that left him unable to walk or transfer by himself. His dementia has worsened and the dr suggested Seroquel and I told her my reservations - she suggested some other meds like Seroquel and we are considering those. You may want to discuss with your mom's dr about the Seroquel - removing that may help if it seems to be worsening her symptoms, but for some it does help. There is another med that's specifically for PD dementia, but I don't know much about it. We are at the beginning of the journey with these types of meds as my dad did great for 11 years with PD on his own and only on the Siniment until this fall and the beginning of some dementia. Definitely talk to the neuro about other alternatives.

Salsnh93: This is a question for your mother's physician.